[
    {
        "id": "osp-10982",
        "type": "article-journal",
        "title": "The Association between Human Leukocyte Antigens and Hypertensive End-Stage Renal Failure among Yemeni Patients",
        "author": [
            {
                "family": "Nassar",
                "given": "Mogahid Y."
            },
            {
                "family": "Al-Shamahy",
                "given": "Hassan A."
            },
            {
                "family": "A.",
                "given": "Haitham A."
            }
        ],
        "URL": "https://omanscience.com/en/articles/the-association-between-human-leukocyte-antigens-and-hypertensive-end-stage-renal-failure-among-yemeni-patients",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "15",
        "issue": "2",
        "page": "241-249",
        "DOI": "10.18295/2075-0528.1687",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: Many studies have attempted to locate a connection between various genetic factors and the pathogenesis of certain diseases. A number of these have found human leukocyte antigens (HLAs) to be the most significant genetic factors affecting the susceptibility of an individual to a certain disease. The present casecontrol study aimed to determine the connection between class I and class II HLAs and cases of hypertensive end-stage renal failure (HESRF), as contrasted with healthy controls, in Yemen. Methods: The study was carried out between March 2013 and March 2014 and included 50 HESRF patients attending the Urology & Nephrology Center at Al-Thawra University Hospital in Sana’a, Yemen, and 50 healthy controls visiting the same centre for kidney donation. Among both patients and controls, HLA class I (A, B and C) and class II (DRB1) genotypes were determined by polymerase chain reactions. Results: There was an association (odds ratio: 4.0) with HLA-A9(24) and HESRF, although this was not statistically significant. A significant protective function was found for the HLACW3 and DRB1-8 genes against the development of HESRF. Although HLA-B14 was present in some patients (0.06) and not in the controls, this difference was not statistically significant enough to conclude that HLA-B14 plays a role in the genetic predisposition for end-stage renal disease development. There was a high frequency of HLA-A2, B5, CW6, DRB1-3, DRB1-4 and DRB1-13 in both patients and controls. Conclusion: Although no HLAs were found to play a highly significant role in genetic predisposition to HESRF, certain HLA genes could be considered as protective genes against HESRF development."
    }
]