[
    {
        "id": "osp-12928",
        "type": "article-journal",
        "title": "Short-term results of intravitreal dexamethasone implant (OZURDEX(®)) in treatment of recalcitrant diabetic macular edema: A case series",
        "author": [
            {
                "family": "Rishi",
                "given": "Pukhraj"
            },
            {
                "family": "Rishi",
                "given": "Ekta"
            },
            {
                "family": "Kuniyal",
                "given": "Lakshmi"
            },
            {
                "family": "Mathur",
                "given": "Gaurav"
            }
        ],
        "URL": "https://omanscience.com/en/articles/short-term-results-of-intravitreal-dexamethasone-implant-ozurdex-in-treatment-of-recalcitrant-diabetic-macular-edema-a-case-series",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2012
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "5",
        "issue": "2",
        "page": "79-82",
        "DOI": "10.4103/0974-620x.99368",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Context: Dexamethasone Posterior-Segment Drug Delivery System is a novel, biodegradable, sustained-release drug delivery system (OZURDEX(®)) for treatment of macular edema following retinal vein occlusion and posterior uveitis. However, its potential role in management of diabetic macular edema has not been reported yet.\n\nAim: The aim was to evaluate the safety and efficacy of (OZURDEX(®)) in patients with recalcitrant diabetic macular edema (DME).\n\nSetting and design: A retrospective, interventional case series from a tertiary eye care center in India is presented. Inclusion criteria comprised patients presenting with recalcitrant DME, 3 or more months after one or more treatments of macular laser photocoagulation and/or intravitreal anti-vascular endothelial growth factor (VEGF) injections. Exclusion criteria included history of corticosteroid-responsive intraocular pressure (IOP) rise, cataract extraction, or other intraocular surgery within 3 months. The main outcome measure was visual acuity at 1 and 4 months after OZURDEX(®) injection. Secondary outcome measures included change in central macular thickness on Optical coherence tomography (OCT) and changes in IOP following intravitreal OZURDEX(®) implant. Of 18 eyes (17 patients) with recalcitrant diabetic macular edema that underwent OZURDEX(®) implant, three eyes (two patients) had follow-up of more than 3 months post-injection.\n\nResults: Mean age of patients was 56 years. Mean duration of diabetes mellitus was 16.6 years. Systemic control of DM was good as assessed by FBS/PPBS and HbA1c. The pre-operative mean central macular thickness was 744.3 μm and improved to 144 and 570 μm at months 1 and 4, respectively. Preoperative mean BCVA was 0.6 logMAR units and improved to 0.3 and 0.46 logMAR units at month 1 and 4, respectively. The mean follow-up was 4.3 months (range 4-5 months).\n\nConclusion: OZURDEX(®) appears efficacious in management of recalcitrant diabetic macular edema. The results of the ongoing POSURDEX(®) study will elaborate these effects better."
    }
]