[
    {
        "id": "osp-1182",
        "type": "article-journal",
        "title": "Serum γ-glutamyltransferase as Oxidative Stress Marker in Pre-and Postmenopausal Iraqi Women",
        "author": [
            {
                "family": "Abdul-Rasheed",
                "given": "Omar F."
            },
            {
                "family": "Al-Shamma",
                "given": "Ghassan A."
            },
            {
                "family": "Zillo",
                "given": "Bushra H."
            }
        ],
        "URL": "https://omanscience.com/en/articles/serum-glutamyltransferase-as-oxidative-stress-marker-in-pre-and-postmenopausal-iraqi-women",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2010
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2010.83",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: The primary role of γ-glutamyltransferase is to metabolize reduced glutathione by assimilating and utilizing precursor amino acids for intracellular glutathione synthesis. The aim of this study is to investigate the exact role of γ-glutamyltransferase enzyme in the oxidative stress associated with menopause. Methods: This study was carried out at the Chemistry and Biochemistry department, Al-Nahrain University from October 2009 to January 2010. The study participants were categorized into two groups; premenopausal group (n=17) and postmenopausal group (n=16). Blood specimens were collected from each participant by vein puncture procedure. The g-glutamyltransferase enzyme was measured by kinetic spectrophotometric method while glutathione and malondialdehyde were measured by spectrophotometric methods. Results: Serum glutathione levels in pre- and postmenopausal women were 0.62±0.17 and 0.47±0.11 mmol/L respectively. Serum g-glutamyltransferase levels increased significantly in the postmenopausal women group (p=0.025) compared to the premenopausal women group. Serum malondialdehyde levels were 1.04±0.06 and 1.32±0.05 µmol/L in pre- and postmenopausal groups respectively. Conclusion: Serum g-glutamyltransferase may be considered as an index of oxidative stress associated with menopause."
    }
]