[
    {
        "id": "osp-10062",
        "type": "article-journal",
        "title": "Predictors of Developing a Complex Course of Osteomyelitis in Patients with Sickle Cell Anaemia",
        "author": [
            {
                "family": "Al Hashmi",
                "given": "Al Zahra"
            },
            {
                "family": "Al Fazari",
                "given": "Ethar"
            },
            {
                "family": "Al Ward",
                "given": "Mustafa"
            },
            {
                "family": "Al Masruri",
                "given": "Reema"
            },
            {
                "family": "Al Balushi",
                "given": "Shahad"
            },
            {
                "family": "Al Mutani",
                "given": "Mohammed"
            },
            {
                "family": "Al Ghaithi",
                "given": "Ahmed"
            },
            {
                "family": "Al Baluki",
                "given": "Wafa"
            }
        ],
        "URL": "https://omanscience.com/en/articles/predictors-of-developing-a-complex-course-of-osteomyelitis-in-patients-with-sickle-cell-anaemia",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "24",
        "issue": "1",
        "page": "58-62",
        "DOI": "10.18295/squmj.12.2023.083",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: Despite the numerous advances in management strategies, treating osteomyelitis in individuals with sickle cell disease (SCD) remains a significant challenge, leading to severe long-term consequences. This study aimed to assess the key factors potentially linked to a complex progression of osteomyelitis in patients diagnosed with SCD. Methods: A cohort of 34 patients was identified and their progress was monitored over a span of 12 months during a 10-year period (2010–2020). The variables under investigation encompassed demographic and clinical traits, laboratory analyses and imaging data, as well as the treatment strategies employed. Results: The risk prediction model pinpointed 5 factors (severity of SCD, involvement of lower limbs, presence of bacteraemia, magnetic resonance image [MRI] findings and utilisation of surgical debridement) that exhibited an area under the curve (AUC) exceeding 0.7. Causative organisms were identified in 9 out of the total 34 patients (26.47%). A total of 17 patients displayed a severe course of SCD (AUC = 7.88), with MRI being highlighted as a valuable contributing factor (AUC = 7.88). Furthermore, 13 patients (38.2%) underwent surgical debridement, a procedure that yielded a statistically significant P value of 0.012 and an AUC of 0.714. Conclusion: Osteomyelitis within the context of severe SCD, particularly when accompanied by lower extremity infection, bacteraemia, positive MRI findings and the need for surgical debridement, emerges as a cluster of risk factors predisposing individuals to osteomyelitis relapse and a more complex disease course.\n\nKeywords: Anemia, sickle cell; Bacteremia; Debridement; Disease Severity; Osteomyelitis."
    }
]