[
    {
        "id": "osp-12168",
        "type": "article-journal",
        "title": "Peripapillary nerve fiber layer in patients with iron deficiency anemia: A cross-sectional study in a tertiary eye care center in Central India",
        "author": [
            {
                "family": "Joshi",
                "given": "Rajesh Subhash"
            },
            {
                "family": "Ingle",
                "given": "Rajesh Namdeo"
            }
        ],
        "URL": "https://omanscience.com/en/articles/peripapillary-nerve-fiber-layer-in-patients-with-iron-deficiency-anemia-a-cross-sectional-study-in-a-tertiary-eye-care-center-in-central-india",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2023
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "16",
        "issue": "2",
        "page": "263-267",
        "DOI": "10.4103/ojo.ojo_252_22",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Aims: The aim of this study is to evaluate the effect of iron-deficiency anemia (IDA) on peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography (SD-OCT).\n\nSettings: The study was conducted at tertiary eye care center in Central India.\n\nDesign: This study was a prospective, cross-sectional, case-control, and observational study.\n\nMaterials and methods: In the present study, 58 eyes of patients with IDA were compared with 58 eyes of healthy individuals. All individuals underwent a thorough hematological, clinical, and ophthalmic examination, followed by peripapillary RNFL analysis using SD-OCT.\n\nResults: A total of 116 eyes were included in the study. The average RNFL thickness (RNFLT) in the cases was 97.26 ± 5.96, and 102.32 ± 6.26 (P = 0.005) in controls. There was a significant RNFL loss in the temporal (66.76 ± 6.1, P = 0.02), superior (119.66 ± 10.47, P = 0.01), nasal (73.59 ± 9.52, P = 0.003), and inferior (129.05 ± 10.96, P = 0.001) quadrants in the cases and controls. Serum hemoglobin, iron, ferritin, total iron-binding capacity, and transferrin saturation were lower in the cases (P < 0.05). A positive correlation was observed between average RNFLT and hemoglobin (r = 0.321), iron (r = 0.122), ferritin (r = 0.152), and transferrin (r = 0.190) levels.\n\nConclusions: In patients with IDA, RNFLT was decreased in all quadrants compared to normal healthy individuals. The inferior and nasal RNFL showed a significant decrease in thickness. The presence of myopia, glaucoma, and diabetic and hypertensive retinopathy can exert an additive effect in the thinning of RNFLs and cause significant visual loss; hence, the correction of anemia is essential. There is a pressing need to raise public and health professional awareness of these problems and their prevention, diagnosis, and management."
    }
]