[
    {
        "id": "osp-2561",
        "type": "article-journal",
        "title": "Perineum Spindle Cell Sarcoma in Neurofibromatosis Type 1",
        "author": [
            {
                "family": "Sandrasecra",
                "given": "Sanjeev"
            },
            {
                "family": "Vasan",
                "given": "Senthil"
            },
            {
                "family": "Henry",
                "given": "Fitjerald"
            },
            {
                "family": "Abdullah",
                "given": "Salmi"
            },
            {
                "family": "Hashim",
                "given": "Mohd Nizam Md"
            },
            {
                "family": "Merican",
                "given": "Siti Rahmah Hashim Isa"
            },
            {
                "family": "Wong",
                "given": "Michael Pak-Kai"
            }
        ],
        "URL": "https://omanscience.com/en/articles/perineum-spindle-cell-sarcoma-in-neurofibromatosis-type-1",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2023
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2023.08",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Soft tissue neoplasm is common among patients with neurofibromatosis type 1 (NF-1). We present a case of a middle-aged woman with NF-1 who presented with a painless, insidiously increasing perineal mass for the past eight months. She underwent colonoscopy, computed tomography staging, magnetic resonance imaging of the pelvis, core-needle biopsy, and later wide local excision of left perineum swelling. Histopathological examination showed a high-grade spindle cell sarcoma, which is a rare association among NF-1. Spindle cell sarcoma is a group of malignant soft tissue tumors with locally destructive growth with spindle-shaped neoplastic cells. The solitary spindle cell sarcoma of the perineum is rare, and wide local resection with a clear margin is the only treatment at present—the scarcely available evidence limiting the use of adjuvant chemotherapy, immunotherapy, and radiotherapy."
    }
]