[
    {
        "id": "osp-11109",
        "type": "article-journal",
        "title": "Ozone-Oxidative Preconditioning Prevents Doxorubicin-induced Cardiotoxicity in Sprague-Dawley Rats",
        "author": [
            {
                "family": "Delgado-Roche",
                "given": "Livan"
            },
            {
                "family": "Hernández-Matos",
                "given": "Yanet"
            },
            {
                "family": "Morejón",
                "given": "Emilio A."
            },
            {
                "family": "Á.",
                "given": "Dalia"
            },
            {
                "family": "González",
                "given": "Maité R."
            },
            {
                "family": "Martίnez-Sánchez",
                "given": "Gregorio"
            }
        ],
        "URL": "https://omanscience.com/en/articles/ozone-oxidative-preconditioning-prevents-doxorubicin-induced-cardiotoxicity-in-sprague-dawley-rats",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "14",
        "issue": "3",
        "page": "342-348",
        "DOI": "10.18295/2075-0528.1597",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: Induced dilated cardiomyopathy is the main limitation of the anti-cancer drug doxorubicin, which causes oxidative stress and cardiomyocyte death. As ozone therapy can activate the antioxidant systems, this study aimed to investigate the therapeutic efficacy of ozone-oxidative preconditioning against doxorubicin-induced cardiotoxicity. Methods: The study was carried out from September 2013 to January 2014. Sprague-Dawley rats were randomly distributed in the following treatment groups: Group 1 were treated with 2 mg/kg intraperitoneal (i.p.) of doxorubicin twice a week for 50 days; Group 2 were treated with 0.3 mg of ozone/oxygen mixture at 50 μg/ mL of ozone per 6 mL of oxygen by rectal insufflation and then treated with doxorubicin; Group 3 were treated as Group 2 but only with the oxygen, and Group 4 were treated with oxygen first, and then with sodium chloride i.p. as the control group. Results: The results showed that ozone therapy preserved left ventricle morphology which was accompanied by a reduction of serum pro-brain natriuretic peptide levels. The cardioprotective effects of ozoneoxidative preconditioning were associated with a significant increase (P"
    }
]