[
    {
        "id": "osp-2591",
        "type": "article-journal",
        "title": "Mycophenolate Induced Colitis: One-year Post-kidney Transplantation",
        "author": [
            {
                "family": "Al Saadi",
                "given": "Waleed"
            },
            {
                "family": "Al Salmi",
                "given": "Issa"
            },
            {
                "family": "Mohammed",
                "given": "Ehab"
            },
            {
                "family": "Al Ajmi",
                "given": "Zakiya"
            },
            {
                "family": "Hannawi",
                "given": "Suad"
            }
        ],
        "URL": "https://omanscience.com/en/articles/mycophenolate-induced-colitis-one-year-post-kidney-transplantation",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2023
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2023.14",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "The incidence of end-stage kidney disease (ESKD) has been increasing over the past few years as a direct result of the growing percentages of individuals with metabolic syndrome. From 2001 to 2015 there were 2805 individuals diagnosed with ESKD in Oman with a growing number of patients undergoing renal transplant as the gold standard management of renal replacement therapy. Mycophenolate mofetil (MMF) is one of the most frequently used medications as a part of immunosuppressive medications in renal transplant specifically and solid organ transplant generally. We are reporting a case of MMF-induced colitis in a young female patient that underwent a living-related kidney transplant. She presented with a three-month history of watery non-bloody and afebrile diarrhea. Investigations confirmed the diagnosis of MMF-induced colitis. Histopathological examination of colonic biopsies obtained during the colonoscopy procedure showed mildly increased crypt apoptosis, mild architectural disarray, and focal crypt attenuation; features consistent with MMF-induced colitis. The patient was treated by stopping the causative agent and replacing it with another immunosuppressive medication, which led to complete resolution of the symptoms on follow-up appointments. In this case report, we highlighted the underlying mechanism, pathogenesis, and clinical features of MMF-induced colitis."
    }
]