[
    {
        "id": "osp-10343",
        "type": "article-journal",
        "title": "Is There an Association between Variceal Bleed and Helicobacter pylori Infection in Cirrhotic Patients with Portal Hypertension?",
        "author": [
            {
                "family": "Varuna",
                "given": "Sathyanarayan"
            },
            {
                "family": "Sureshkumar",
                "given": "Sathasivam"
            },
            {
                "family": "Gurushankari",
                "given": "Balakrishnan"
            },
            {
                "family": "Archana",
                "given": "Elangovan"
            },
            {
                "family": "Mohsina",
                "given": "Subair"
            },
            {
                "family": "Kate",
                "given": "Vikram"
            },
            {
                "family": "Balasubramanian",
                "given": "Vairappan"
            },
            {
                "family": "Mahalakshmy",
                "given": "Thulasingam"
            }
        ],
        "URL": "https://omanscience.com/en/articles/is-there-an-association-between-variceal-bleed-and-helicobacter-pylori-infection-in-cirrhotic-patients-with-portal-hypertension",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "22",
        "issue": "4",
        "page": "539-545",
        "DOI": "10.18295/squmj.9.2021.136",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: This study aimed to determine the association between Helicobacter pylori infection and variceal bleeding as well as rebleeding in cases of cirrhosis with portal hypertension. Methods: This prospective cohort study included patients with bleeding oesophageal varices and was conducted at the Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India, from August 2016 to July 2018. Results: A total of 190 patients were assessed for eligibility, of which 159 patients were included in this study. Among the 159 patients, 124 (78.0%) had alcohol-related liver disease and eight had hepatitis B virus-related liver disease. Seven patients with varices had bled neither at presentation nor during the follow-up period. A total of 78 (49.1%) patients were H. pylori infected. The primary outcome, which was correlation between prevalence of H. pylori and the incidence of bleeding/rebleeding from varices as well as encephalopathy found that patients with oesophageal varices (adjusted risk [AR] = 0.714) and H. pylori infection (AR = 0.682) had a lower risk of variceal rebleeding. Among H. pylori-negative patients, pepsinogen I was higher in patients with rebleeding (30.7 versus 14.4 ng/mL; P"
    }
]