[
    {
        "id": "osp-10828",
        "type": "article-journal",
        "title": "Intravenous Remifentanil Analgaesia for an Obstetric Patient with Type I Neurofibromatosis and a Factor V Leiden Mutation",
        "author": [
            {
                "family": "Gálvez",
                "given": "José L."
            },
            {
                "family": "Errando",
                "given": "Carlos L."
            },
            {
                "family": "Martín-Ayuso",
                "given": "Silvia"
            },
            {
                "family": "Marga",
                "given": ""
            },
            {
                "family": "Valverde-Mantecón",
                "given": "José M."
            }
        ],
        "URL": "https://omanscience.com/en/articles/intravenous-remifentanil-analgaesia-for-an-obstetric-patient-with-type-i-neurofibromatosis-and-a-factor-v-leiden-mutation",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "17",
        "issue": "4",
        "page": "468-471",
        "DOI": "10.18295/squmj.2017.17.04.016",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Type I neurofibromatosis is characterised by altered skin pigmentation and the growth of benign tumours, particularly along the peripheral nerves and central nervous system. We report a 36-year-old primigravida woman in labour who was admitted to the obstetric suite of the Hospital Sant Joan de Déu, Barcelona, Spain, in 2007 with hypothyroidism, type I neurofibromatosis and a factor V Leiden mutation. Due to a lack of cranial and spinal imaging data, an epidural was not indicated; instead, continuous intravenous remifentanil analgaesia was administered. The remifentanil infusion was self-titrated by the patient using a visual analogue scale, with the dosage ranging from 0.01 to 0.25 μg/kg/minute. Due to rotational dystocia, Kjelland-type forceps were used during the delivery. After birth, the infant was found to have Apgar scores of 9 and 10, with no maternal or neonatal adverse effects observed. Although still controversial, remifentanil may be a successful alternative for analgaesia in similar cases; however, the specific risks and benefits for each patient should be considered prior to administration."
    }
]