[
    {
        "id": "osp-13029",
        "type": "article-journal",
        "title": "Indirect evaluation of corneal apoptosis in contact lens wearers by estimation of nitric oxide and antioxidant enzymes in tears",
        "author": [
            {
                "family": "Bhatia",
                "given": "R P"
            },
            {
                "family": "Dhawan",
                "given": "Shikha"
            },
            {
                "family": "Khanna",
                "given": "H D"
            },
            {
                "family": "Dash",
                "given": "Amitabh"
            }
        ],
        "URL": "https://omanscience.com/en/articles/indirect-evaluation-of-corneal-apoptosis-in-contact-lens-wearers-by-estimation-of-nitric-oxide-and-antioxidant-enzymes-in-tears",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2010
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "3",
        "issue": "2",
        "page": "66-69",
        "DOI": "10.4103/0974-620x.64229",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Background: Contact lens induced trauma to the corneal epithelium results in increased release of inflammatory mediators. The keratocyte apoptosis is directly related to epithelial injury and has been correlated with increased production of nitric oxide. Potent antioxidant enzymes protect cells from oxidative damage by inactivating reactive oxygen species and thus inhibiting apoptosis. This study aims at determination of total nitric oxide and antioxidant enzymes in tears which will be an indirect criteria for assessing apoptosis.\n\nMaterials and methods: Nitric oxide and antioxidant enzymes were estimated in tears of 25 soft contact lens wearers and compared with 25 age and sex matched controls.\n\nResults: Statistically significant increase of nitric oxide (P"
    }
]