[
    {
        "id": "osp-1237",
        "type": "article-journal",
        "title": "In Vitro α-Amylase Inhibition and Antioxidant Activities of Methanolic Extract of Amaranthus Caudatus Linn",
        "author": [
            {
                "family": "BS",
                "given": "Ashok Kumar"
            },
            {
                "family": "K",
                "given": "Lakshman"
            },
            {
                "family": "KN",
                "given": "Jayaveera"
            },
            {
                "family": "D",
                "given": "Sheshadri Shekar"
            },
            {
                "family": "VB",
                "given": "Narayan Swamy"
            },
            {
                "family": "Khan",
                "given": "Saleemulla"
            },
            {
                "family": "C",
                "given": "Velumurga"
            }
        ],
        "URL": "https://omanscience.com/en/articles/in-vitro-amylase-inhibition-and-antioxidant-activities-of-methanolic-extract-of-amaranthus-caudatus-linn",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2011
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2011.40",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: The present study was aimed to investigate the α-amylase inhibition and antioxidant activities of methanolic extract of Amaranthus caudatus Linn (MeAc). Methods: Methanolic extract of Amaranthus caudatus was screened for α-amylase inhibition activity by CNPG3 method (2-chloro-p-nitrophenyl-α-D-maltotrioside) and antioxidant activity was evaluated by 1,1-diphenyl-2-picryl-hydrazile (DPPH) free radical scavenging, superoxide dismutase (SOD) scavenging, hydroxyl free radical scavenging, nitric oxide (NO) radical scavenging, and 2.2’-azinobis-3-ethylbenzothiazole-6-sulfonic acid (ABTS) radical scavenging assays. MeAc was also screened for non enzymatic hemoglycosylation. Results: The methanolic extract of Amaranthus caudatus showed potent α-amylase inhibition activity (IC50 19.233 µg/ml). MeAc showed significant antioxidant activity in all the in vitro antioxidant models. Furthermore, the MeAc was found to be extremely effective in scavenging ABTS radical activity (IC50 48.75±1.1 µg/ml) when compared to DPPH (IC50 77.5±0.4 µg/ml), SOD (IC50 62.5±2.1 µg/ml), hydroxyl (IC50 88.50±1.8 µg/ml) and NO (IC50 67.5±2.2 µg/ml) scavenging activity. Conclusions: The methanolic extract of A. caudatus showed potent α-amylase inhibition and antioxidant activities."
    }
]