[
    {
        "id": "osp-14382",
        "type": "article-journal",
        "title": "HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction",
        "author": [
            {
                "family": "Küçük",
                "given": "Uğur"
            },
            {
                "family": "Sılan",
                "given": "Fatma"
            },
            {
                "family": "Gazi",
                "given": "Emine"
            },
            {
                "family": "Özdemir",
                "given": "Öztürk"
            },
            {
                "family": "Arslan",
                "given": "Kadir"
            },
            {
                "family": "Sönmez",
                "given": "Volkan"
            },
            {
                "family": "Akşit",
                "given": "Ercan"
            }
        ],
        "URL": "https://omanscience.com/en/articles/hla-dq2-and-hla-dq8-haplotypes-in-heart-failure-patients-with-reduced-ejection-fraction",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "volume": "40",
        "issue": "4",
        "DOI": "10.5001/omj.2025.98",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: Genetic predisposition is one of the factors that contribute to the etiology of heart failure (HF). This study aimed to compare the prevalence of human leukocyte antigen (HLA)-DQ2 and HLA-DQ8 haplotypes in patients with HF with reduced ejection fraction (HFrEF) and healthy controls. Methods: This case control study was conducted in Western Türkiye, and included 100 participants: 50 patients diagnosed with HFrEF and 50 healthy matching controls. The frequency and distribution of HLA-DQ2 and HLA-DQ8 were compared between the groups. Results: No statistically significant differences in haplotype distribution were observed between patients and controls for any of the assessed parameters. HLA-DQ2 positivity was observed in 16.0% of the HFrEF group and 20.0% of controls, while HLA-DQ8 positivity was found in 24.0% and 26.0%, respectively. Subgroup analyses stratified by sex and HF etiology also did not reveal differences. Conclusions: The HLA-DQ2 and HLA-DQ8 haplotypes are not significantly associated with HFrEF in the population studied. Therefore, the utility of these haplotypes as standalone markers for early detection of HFrEF appears limited."
    }
]