[
    {
        "id": "osp-12485",
        "type": "article-journal",
        "title": "Ganglion cell complex loss in patients with type 1 diabetes: A 36-month retrospective study",
        "author": [
            {
                "family": "Thangamathesvaran",
                "given": "Loka"
            },
            {
                "family": "Kommana",
                "given": "Sumana S"
            },
            {
                "family": "Duong",
                "given": "Kim"
            },
            {
                "family": "Szirth",
                "given": "Bernard"
            },
            {
                "family": "Khouri",
                "given": "Albert S"
            }
        ],
        "URL": "https://omanscience.com/en/articles/ganglion-cell-complex-loss-in-patients-with-type-1-diabetes-a-36-month-retrospective-study",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2019
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "12",
        "issue": "1",
        "page": "31-36",
        "DOI": "10.4103/ojo.ojo_224_2017",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Background: To analyze changes over a 3-year period in ganglion cell complex (GCC) thickness in individuals with type 1 diabetes mellitus (T1DM) using spectral-domain optical coherence tomography (Optovue, Fremont, CA, USA).\n\nMethods: Thirty-seven individuals from \"Friends for Life Conference\" with T1DM and a 3-year history of GCC thickness measurements were included in the study. Data analysis using SPSS 22 and Excel StatPlus was completed to note the subgroups that had a significant change.\n\nResults: Significant decreases were noted in the following subgroups with slope in parenthesis. Overall: GCC superior thickness OD (-0.48)Male: GCC thickness OD (-0.86), GCC superior thickness OD (-0.735)Body mass index (BMI) 25.0-29.9: GCC thickness OD (-0.48), GCC superior thickness OS (-0.915), GCC inferior thickness OD (-0.43)Ages 10-20 years: GCC superior thickness OD (-0.635)Duration of diabetes 10-20 years: GCC thickness OD (-1.055), GCC superior thickness OD (-0.99).\n\nConclusion: GCC loss was noted in individuals who were males, those with BMIs of 25.0-29.9, and those who had diabetes for 10-20 years. Ganglion cell loss was also noted before the presence of any diabetic retinopathy, suggesting onset of neuronal loss before any vasculature changes."
    }
]