[
    {
        "id": "osp-11062",
        "type": "article-journal",
        "title": "Frequency of Glomerular Dysfunction in Children with Beta Thalassaemia Major",
        "author": [
            {
                "family": "Ali",
                "given": "Basma A."
            },
            {
                "family": "Mahmoud",
                "given": "Ahmed M."
            }
        ],
        "URL": "https://omanscience.com/en/articles/frequency-of-glomerular-dysfunction-in-children-with-beta-thalassaemia-major",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "14",
        "issue": "1",
        "page": "88-94",
        "DOI": "10.18295/2075-0528.1551",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: This study investigated the frequency of glomerular dysfunction in children with beta thalassaemia major (β-TM) by using different markers and correlating them with serum ferritin and iron chelation therapy. Methods: The study, carried out between August 2011 and May 2012, included 100 patients with β-TM, in two groups. Group Ia (n = 62) received chelation therapy (deferoxamine). Group Ib (n = 38) received followup care at the Pediatric Hematology Outpatient Clinic, Minia University Children’s Hospital, Egypt. Group II included 50 apparently healthy controls, age- and sex-matched to Group I. All patients underwent a thorough history-taking, clinical examination and laboratory investigations. Results: Compared to Group II, Groups Ia and Ib had significantly higher levels of cystatin C, serum creatinine and serum ferritin, and a higher albumin/ creatinine ratio in their urine, and a significantly lower estimated glomerular filtration rate (eGFR) and creatinine clearance (P"
    }
]