[
    {
        "id": "osp-1587",
        "type": "article-journal",
        "title": "Familial Clustering of Type 2 Diabetes among Omanis",
        "author": [
            {
                "family": "Al-Sinani",
                "given": "Sawsan"
            },
            {
                "family": "Al-Shafaee",
                "given": "Mohammed"
            },
            {
                "family": "Al-Mamari",
                "given": "Ali"
            },
            {
                "family": "Woodhouse",
                "given": "Nicholas"
            },
            {
                "family": "Al-Shafie",
                "given": "Omaima"
            },
            {
                "family": "Hassan",
                "given": "Mohammed"
            },
            {
                "family": "Al-Yahyaee",
                "given": "Said"
            },
            {
                "family": "Albarwani",
                "given": "Sulayma"
            },
            {
                "family": "Jaju",
                "given": "Deepali"
            },
            {
                "family": "Al-Hashmi",
                "given": "Khamis"
            },
            {
                "family": "Al-Abri",
                "given": "Mohammed"
            },
            {
                "family": "Rizvi",
                "given": "Syed"
            },
            {
                "family": "Bayoumi",
                "given": "Riad"
            }
        ],
        "URL": "https://omanscience.com/en/articles/familial-clustering-of-type-2-diabetes-among-omanis",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2014
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2014.11",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "The aim of this study was to screen Omani individuals for the familial aggregation of type 2 diabetes mellitus. A random cohort of 1182 Omani individuals visiting the Family Medicine Clinic at Sultan Qaboos University Hospital (SQUH), Muscat, Oman, for regular medical checkup, aged ≥40 years, were sampled. Patients were categorized into three groups: (1) individuals who claim not to have diabetes and had no family history of diabetes; (2) individuals who claim not to have diabetes but had family history of diabetes; (3) individuals with diabetes. Only 16% of these Omani individuals had no diabetes and no family history of diabetes. Another separate random cohort of 234 Omani type 2 diabetes mellitus patients, from the Diabetes Clinic at SQUH, were interviewed and questioned about their family history of type 2 diabetes mellitus. Ninety five percent of the patients had a family history of diabetes. Eighty percent had first degree relatives with diabetes and 46% had second degree relatives with diabetes. At least one parent with diabetes was reported among 55% of these diabetics, while maternal diabetes (55%) was found to be higher than paternal diabetes (47%). However, only 15% had both parents with diabetes. Furthermore, almost half of the 234 diabetics were having at least one of the following relatives with diabetes: brother, sister, aunt or an uncle. The findings of this study confirm familial aggregation of diabetes among the Omani population. Compared to other populations, familial aggregation of type 2 diabetes mellitus among Omanis is relatively very high, and is perhaps due to the very high degree of consanguinity among Omanis. Since almost everyone seems to have a genetic predisposition to diabetes, the dramatic lifestyle changes over the past 25 years, could tip the population into an epidemic of type 2 diabetes mellitus."
    }
]