[
    {
        "id": "osp-11844",
        "type": "article-journal",
        "title": "Evaluation of optical coherence tomography in patients with coronary artery disease and systemic hypertension",
        "author": [
            {
                "family": "Bhardwaj",
                "given": "Shikha"
            },
            {
                "family": "Abrar",
                "given": "Farhat"
            }
        ],
        "URL": "https://omanscience.com/en/articles/evaluation-of-optical-coherence-tomography-in-patients-with-coronary-artery-disease-and-systemic-hypertension",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2026
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "19",
        "issue": "2",
        "page": "204-209",
        "DOI": "10.4103/ojo.ojo_245_25",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Background: Systemic hypertension and coronary artery disease (CAD) cause widespread vascular and neurodegenerative changes, including in the retina. Optical coherence tomography (OCT) offers a noninvasive means to visualise these changes, serving as a potential marker of systemic vascular health. Retinal layers like the peripapillary retinal nerve fiber layer (p-RNFL) and ganglion cell-inner plexiform layer (GC-IPL) are especially vulnerable to vascular damage, making them useful indicators of cardiovascular risk. This study aimed to evaluate and compare the p-RNFL and GC-IPL thickness among hypertensive individuals with and without CAD and healthy controls.\n\nMaterials and methods: This prospective observational study included 140 participants divided into three groups: healthy controls (Group A, n = 40), hypertensives without CAD (Group B, n = 50), and hypertensives with CAD (Group C, n = 50). All subjects underwent comprehensive ophthalmic evaluation, including spectral-domain-OCT, to measure p-RNFL and GC-IPL thickness in both eyes. Data were analyzed using analysis of variance with a significance threshold of P < 0.05.\n\nResults: Both p-RNFL and GC-IPL were significantly thinned in hypertensive subjects, especially those with CAD. Group A had the highest mean RNFL (114.11 ± 10.09 μm) and GC-IPL (85.07 ± 2.30 μm), whereas Group C showed the lowest (RNFL: 84.90 ± 11.81 μm; GC-IPL: 105.97 ± 11.72 μm). Differences were significant (P < 0.001).\n\nConclusion: OCT can find early signs of retinal nerve damage related to high blood pressure and CAD, indicating it can be a helpful noninvasive method for checking and tracking heart health risks."
    }
]