[
    {
        "id": "osp-1405",
        "type": "article-journal",
        "title": "Estimated Glomerular Filtration rate (eGFR): A Serum Creatinine-based Test for the Detection of Chronic Kidney Disease and its Impact on Clinical Practice",
        "author": [
            {
                "family": "Mula-Abed",
                "given": "Waad-Allah S."
            }
        ],
        "URL": "https://omanscience.com/en/articles/estimated-glomerular-filtration-rate-egfr-a-serum-creatinine-based-test-for-the-detection-of-chronic-kidney-disease-and-its-impact-on-clinical-practice-3",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2012
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2012.87",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "We appreciate the interesting comment raised by Jain et al. concerning the review on estimated Glomerular Filtration Rate (eGFR) and its implication on clinical practice. They question the need for developing specific eGFR equations for each population including those in the Middle East that may be related to racial variation in body composition. The comparison of six equations by Jain et al. should inspire future studies. However, the issue, though valid, is subject to practical pitfalls when utilising its application. All publications implementing the MDRD and CKD.EPI equations do not include correction factors for weight or race, and preserving a factor of 1.212 only to African Americans when using MDRD and none when using CKD.EPI. The increase of multi cultural communities does not ease deriving and validating different equations for the different populations. For our community in the Middle East, only serum creatinine, age and sex are currently utilised for calculating the eGFR by the aforementioned equations, and the non-requirement for including weight or height has contributed in the widespread acceptance of these equations by both pathologists and clinicians. In our practice, using serum-creatinine based eGFR reporting has eased and improved the awareness of the clinicians towards the interpretation of renal function test in screening and management of different diseases. While few requestors are aware about the reference ranges for serum creatinine, however almost all are familiar with the eGFR ranges in healthy subjects and in different stages of chronic kidney diseases (CKD). Despite the concern about the increasing patients’ referral to nephrologists based on eGFR diagnosis of CKD, the overall concept is fulfilling the eGFR use as a screening test for early detection of renal impairment which is better than serum creatinine alone for this task."
    }
]