[
    {
        "id": "osp-1869",
        "type": "article-journal",
        "title": "Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015",
        "author": [
            {
                "family": "Gaifer",
                "given": "Zied"
            },
            {
                "family": "Babiker",
                "given": "Ahmed"
            },
            {
                "family": "Rizavi",
                "given": "Dawar"
            }
        ],
        "URL": "https://omanscience.com/en/articles/epidemiology-of-drug-resistant-tuberculosis-in-a-tertiary-care-center-in-oman-2006-2015",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2017
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2017.07",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman. Methods: We performed a cross-sectional review of culture-confirmed tuberculosis (TB) cases diagnosed at Sultan Qaboos University Hospital between August 2006 and March 2015. We compared drug-resistant TB cases with drug-sensitive cases to identify predictors of drug-resistant TB using univariate and multivariate logistic regression analysis. Results: Of the 260 TB cases reviewed, 73.1% were confirmed by culture. The proportion of multi-drug resistant TB was 1.8%. TB isolates resistant to any of the first-line TB drugs comprised (7.5%) of cases. Pyrazinamide monoresistance was the most frequently reported drug monoresistant pattern (3.5%). Previous treatment for TB (odds ratio (OR) 14.81; 95% CI 3.09−70.98, p < 0.001), female gender (OR 3.85; 95% Cl 1.07−13.90, p < 0.039), and younger age (OR 6.80; 95% Cl 1.61−28.75, p < 0.009) were found to be risk factors for development of first-line antituberculosis drug-resistant TB in multivariate analysis. Conclusions: Our results show that the rate of drug-resistant TB in our population is a public health issue of great concern. Previous treatment with antituberculosis drugs, female gender, and younger age are risk factors for the development of drug-resistant TB. These findings are useful adjuvants to guide clinicians and public health professionals in the early detection and appropriate treatment of cases of drug-resistant TB."
    }
]