[
    {
        "id": "osp-10475",
        "type": "article-journal",
        "title": "Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome: A systematic review and meta-analysis",
        "author": [
            {
                "family": "Asha",
                "given": "Mohammad Z."
            },
            {
                "family": "Khalil",
                "given": "Sundos FH"
            }
        ],
        "URL": "https://omanscience.com/en/articles/efficacy-and-safety-of-probiotics-prebiotics-and-synbiotics-in-the-treatment-of-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "20",
        "issue": "1",
        "page": "e13-24",
        "DOI": "10.18295/squmj.2020.20.01.003",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Treatments that target alterations in gut microbiota may be beneficial for patients with irritable bowel syndrome (IBS). A systematic review and meta-analysis was conducted of randomised clinical trials (RCTs) evaluating the efficacy and safety of probiotics, prebiotics and synbiotics. Factors considered in the analysis included global IBS symptoms and/or abdominal pain, secondary symptoms and the frequency of adverse events. A total of 33 RCTs involving 4,321 patients were identified. Overall, probiotics significantly improved global IBS symptoms compared to placebos (standardised mean difference = −0.32, 95% confidence interval: −0.48 to −0.15; P"
    }
]