[
    {
        "id": "osp-1743",
        "type": "article-journal",
        "title": "Ductal and Acinar Adenocarcinoma of Prostate: Morphological and Immunohistochemical Characterization",
        "author": [
            {
                "family": "Baig",
                "given": "Faraz A."
            },
            {
                "family": "Hamid",
                "given": "Amna"
            },
            {
                "family": "Mirza",
                "given": "Talat"
            },
            {
                "family": "Syed",
                "given": "Serajuddaula"
            }
        ],
        "URL": "https://omanscience.com/en/articles/ductal-and-acinar-adenocarcinoma-of-prostate-morphological-and-immunohistochemical-characterization",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2015
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2015.36",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: We sought to characterize the ductal and acinar subtype of prostate adenocarcinoma using hematoxylin and eosin (H&E) staining and an immunohistochemical antibody cocktail. We also investigated the clinical features, prostate-specific antigen (PSA) levels, and biological aggressiveness of these tumors. Methods: We utilized tumor bearing prostate biopsies, obtained between 2010 and 2014 from Dow Diagnostic Research and Reference Laboratory, to identify cases of prostatic ductal and acinar adenocarcinoma using routine H&E and immunohistochemical staining. The immunohistochemical antibody cocktail 34βE12/p63/AMACR was used for staining. The association of clinicopathological variables including patient’s age at diagnosis, Gleason score, and PSA levels before surgery was retrospectively analyzed. Results: A total of 10 ductal and 140 non-ductal cases were identified. Ductal cases were predominantly high grade with advanced histopathological features (90%; p=0.030). Marked elevation in PSA level was also reported in most cases. No other significant statistical difference was observed. Conclusions: Pathological and immunohistochemical examination could be used to characterize ductal and acinar adenocarcinoma of the prostate. Ductal adenocarcinoma of the prostate is a rare subtype of prostate carcinoma and is be more likely to present with advanced grade cancer suggesting that timely detection of the disease is vital."
    }
]