[
    {
        "id": "osp-9970",
        "type": "article-journal",
        "title": "Assessing Morbidity and Malignancy Risk in Patients Presenting with Pulmonary Embolism in an Ambulatory Care Setting",
        "author": [
            {
                "family": "Memon",
                "given": "Muhammed"
            },
            {
                "family": "Anwar",
                "given": "Eram"
            },
            {
                "family": "Shakir",
                "given": "Kamran"
            },
            {
                "family": "Bouhaddioui",
                "given": "Chafik"
            },
            {
                "family": "Akram",
                "given": "Mueed"
            },
            {
                "family": "Awan",
                "given": "Shakeel"
            },
            {
                "family": "Khalil",
                "given": "Muhammad"
            },
            {
                "family": "Usama",
                "given": "Muhammad"
            },
            {
                "family": "Agha",
                "given": "Adnan"
            }
        ],
        "URL": "https://omanscience.com/en/articles/assessing-morbidity-and-malignancy-risk-in-patients-presenting-with-pulmonary-embolism-in-an-ambulatory-care-setting",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "25",
        "issue": "1",
        "page": "852-858",
        "DOI": "10.18295/2075-0528.2902",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: Venous thromboembolism (VTE), especially pulmonary embolism (PE), can be treated in an outpatient setting after appropriate risk assessment. However, front-door physicians may be resistant to follow this practice. The possibility of cancer-associated VTE complicates the outpatient management of PE. This study aimed to assess the morbidity and mortality in patients with PE who were managed in an emergency/acute medicine-led outpatient clinic as per risk stratification as well as detecting diagnoses of new cancer sites (NCSs) in these patients. Methods: This retrospective study included all patients with confirmed PE managed in an acute medicine outpatient setting at Queens Hospital, Burton-on-Trent, United Kingdom, from 2019 to 2022. Biochemical findings, radiological findings, mortality and morbidity rates, treatment administered, simplified Pulmonary Embolism Severity Index (sPESI) scores, complications and NCS diagnosis were obtained. Results: A total of 82 patients were included in this study; their mean age was 63.3 ± 16.7 years and 56.1% (n = 46) were male. The two commonest presenting complaints were new shortness of breath (25.6%, n = 21) and pleuritic chest pain (19.5%, n = 16). Unprovoked PE was observed in 52.4% (n = 43) of patients. Increased sPESI scores were related to increased mortality rates; sPESI scores of 0 and 3 were associated with 0% and 50% mortality rates within 90 days, respectively. NCS was reported in 13.4% (n = 11). Statistical analyses using logistic regression and classification tree methods revealed that NCS can be predicted with 70.6% sensitivity and 97% specificity using 2 variables (history of cancer and age >73 years). Conclusion: The sPESI can help in the risk stratification of patients with PE showing poor outcomes; patients at a high risk of NCS development can be identified using the classification tree method."
    }
]