[
    {
        "id": "osp-10488",
        "type": "article-journal",
        "title": "Waddling Gait: A complication of valproate therapy and a thought beyond vitamin D deficiency",
        "author": [
            {
                "family": "Sharma",
                "given": "Amit"
            },
            {
                "family": "Sinha",
                "given": "Siddhartha"
            },
            {
                "family": "Narang",
                "given": "Amit"
            },
            {
                "family": "Chouhan",
                "given": "Dushyant K."
            },
            {
                "family": "Gupta",
                "given": "Sumit"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/waddling-gait-a-complication-of-valproate-therapy-and-a-thought-beyond-vitamin-d-deficiency",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "20",
        "issue": "1",
        "page": "e104-108",
        "DOI": "10.18295/squmj.2020.20.01.016",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Proximal muscle weakness is a common presentation in paediatric-orthopaedic clinics and is frequently paired with a vitamin D deficiency diagnosis. Recently, side effects of the extensive use of antiepileptic and antipsychotic drugs such as sodium valproate in childhood disorders are being documented. Sodium valproate causes a time-dependent, drug-induced proximal myopathy. We report a 13-year-old female patient who presented at the Orthopaedic Outpatient Department at Lady Hardinge Medical College, New Delhi, India, in 2019 with an abnormal gait. The patient was taking a combination therapy of sodium valproate, risperidone and trihexyphenidyl for absence seizures and a mood disorder. Following clinical investigations, the patient was diagnosed with proximal myopathy. As a result of elevated serum alkaline phosphatase and creatine kinase myocardial band levels, sodium valproate was replaced with ethosuximide and a carnitine supplementation was prescribed. The patient fully recovered and regained full mobility. Proximal myopathy had been incorrectly managed and assumed to be caused by a vitamin D deficiency."
    }
]