[
    {
        "id": "osp-11278",
        "type": "article-journal",
        "title": "Types of Bacteria associated with Neonatal Sepsis in Al-Thawra University Hospital, Sana’a, Yemen, and their Antimicrobial Profile",
        "author": [
            {
                "family": "Al-Shamahy",
                "given": "Hassan A."
            },
            {
                "family": "Sabrah",
                "given": "Amal A."
            },
            {
                "family": "Naser",
                "given": "Abdul Baki"
            },
            {
                "family": "M.",
                "given": "Samarih"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/types-of-bacteria-associated-with-neonatal-sepsis-in-al-thawra-university-hospital-sana-a-yemen-and-their-antimicrobial-profile",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "12",
        "issue": "1",
        "page": "48-54",
        "DOI": "10.18295/2075-0528.1339",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: This study was undertaken to investigate the organisms causing sepsis in the Neonatal Unit at Al-Thawra Hospital, Sana’a, Yemen, determine their resistance to antibiotics, and recommend policy for empirical treatment. Methods: A total of 158 neonates having one or more signs of sepsis, and aged from 0 to 28 days, were enrolled in this study. A blood sample was taken from each subject, cultured, and then antibacterial susceptibility tests were performed for isolates. Results: 90 (57%) cases yielded positive cultures. Early-onset sepsis showed higher positive culture results (61.7%) than late-onset sepsis (32%). Significant positive culture results were found among the group with birth weight 0.9–2 Kg (78.6%). Gram negative bacteria constituted 97.8% of the total isolates, of which Klebsiella pneumoniae was the predominant pathogen (36.7%), followed by Pseudomonas species (30.0%). The commonest symptoms among the cases were respiratory distress (72.2%), jaundice (62.2%), cyanosis (51.1%), and lethargy (47.8%); the mortality rate was 27.8%. All Gram negative bacterial isolates were sensitive to imipenem and some isolates were sensitive to fourth-generation cephalosporins, but most isolates were highly resistant to the majority of other antibiotics tested. Conclusion: Gram negative organisms were the most frequent causative agents of bacterial sepsis, which is a significant cause of mortality and morbidity in the newborn, and particularly in those of very low birth weight. It can also be concluded that imipenem and fourth-generation cephalosporins can be used for empirical treatment of bacterial sepsis."
    }
]