[
    {
        "id": "osp-9923",
        "type": "article-journal",
        "title": "The Effect of Proton Pump Inhibitors on Bone Mineralisation: A Systematic Review with Focus on PHOSPHO1",
        "author": [
            {
                "family": "Baudin",
                "given": "Célia"
            },
            {
                "family": "Faria-Almeida",
                "given": "Ricardo"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/the-effect-of-proton-pump-inhibitors-on-bone-mineralisation-a-systematic-review-with-focus-on-phospho1",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "25",
        "issue": "1",
        "page": "974-980",
        "DOI": "10.18295/2075-0528.2920",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: Proton pump inhibitors (PPIs) are among the most widely prescribed drugs for long-term suppression of gastric acid. Though generally considered safe, increasing evidence links their use to altered bone metabolism. This systematic review investigates the hypothesis that PPI-induced inhibition on PHOSPHO1-a bone-specific phosphatase- impairs bone mineralisation. Methods: A systematic electronic search was conducted for experimental studies from January 2000 to January 2025. The screening and selection followed PRISMA guidelines. Results: Of 20 articles identified, 3 met the inclusion criteria: two in-vitro studies and one combining both in-vitro and in-vivo data. All three examined the effects of PPIs on bone formation and consistently reported significantly reduced minerallization capacity. Conclusion: The review suggests that PPIs appear to inhibit PHOSPHO1 activity, potentially impairing early-stage bone mineralisation. However, due to the limited number of studies, these findings should be interpreted with caution, and further research is warranted."
    }
]