[
    {
        "id": "osp-13784",
        "type": "article-journal",
        "title": "Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine",
        "author": [
            {
                "family": "N.",
                "given": "Al-Busafi Saleh"
            },
            {
                "family": "M.",
                "given": "Al-Hamami Nadia"
            },
            {
                "family": "Eldin",
                "given": "O. Suliman Fakhr"
            },
            {
                "family": "Beena",
                "given": "Varghese"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/synthesis-of-a-flavone-based-fluorescent-probe-bearing-a-nitroolefin-moiety-for-selective-detection-of-cysteine",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2018
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Journal for Science",
        "volume": "23",
        "issue": "2",
        "page": "85",
        "DOI": "10.24200/squjs.vol23iss2pp85-94",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2308-3921",
        "abstract": "In this paper, we report the synthesis, characterization and investigation of the optical properties of a new fluorescent probe, 4ʹ-nitroolefinylflavone (4ʹ-NOF) 1, based on a flavone skeleton and bearing a nitroolefin moiety. Upon the addition of cysteine, a remarkable fluorescence enhancement (200 fold) was observed for probe 1 accompanied with a slight blue shift from 457 nm to 459 nm. The prepared probe displays high selectivity and sensitivity towards cysteine over other amino acids. The Michael addition of cysteine to probe 1 was confirmed by 1H-NMR spectroscopy. The detection limit of probe 1 towards cysteine was found to be 1.63 μΜ, a lower concentration than the normal human cysteine level, 30-200 μΜ."
    }
]