[
    {
        "id": "osp-11132",
        "type": "article-journal",
        "title": "Non-Invasive Haemoglobin Estimation in Patients with Thalassaemia Major",
        "author": [
            {
                "family": "Al-Khabori",
                "given": "Murtadha K."
            },
            {
                "family": "Al-Riyami",
                "given": "Arwa Z."
            },
            {
                "family": "Al-Huneini",
                "given": "Khalil"
            },
            {
                "family": "Mohammed",
                "given": ""
            },
            {
                "family": "Al-Hashim",
                "given": "Abdul Hakeem"
            },
            {
                "family": "Al-Kemyani",
                "given": "Nasser"
            },
            {
                "family": "Alqarshoubi",
                "given": "Issa"
            },
            {
                "family": "Khan",
                "given": "Hammad"
            },
            {
                "family": "Al-Amrani",
                "given": "Khalfan"
            },
            {
                "family": "Daar",
                "given": "Shahina"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/non-invasive-haemoglobin-estimation-in-patients-with-thalassaemia-major",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "14",
        "issue": "4",
        "page": "468-472",
        "DOI": "10.18295/2075-0528.1620",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: This study aimed to validate pulse CO-oximetry-based haemoglobin (Hb) estimation in children and adults with thalassaemia major (TM) and to determine the impact of different baseline variables on the accuracy of the estimation. Methods: This observational study was conducted over a five-week period from March to April 2012. A total of 108 patients with TM attending the daycare thalassaemia centre of a tertiary care hospital in Muscat, Oman, were enrolled. Spot (Sp) Hb measurements were estimated using a Pronto-7® pulse CO-oximetry device (Masimo Corp., Irvine, California, USA). These were compared to venous samples of Hb using the CELL-DYN Sapphire Hematology Analyzer (Abbott Diagnostics, Abbott Park, Illinois, USA) to determine the reference (Ref) Hb levels. A multivariable linear regression model was used to assess the impact of baseline variables such as age, gender, weight, height, Ref Hb and blood pressure on the Hb estimations. Results: Of the 108 enrolled patients, there were 54 males and 54 females with a mean age of 21.6 years (standard deviation [SD] = 7.3 years; range: 2.5–38 years). The mean Ref Hb and Sp Hb were 9.4 g/dL (SD = 0.9 g/dL; range: 7.5–12.3 g/dL) and 11.1 g/dL (SD = 1.2 g/dL; range: 7.5–14.7 g/dL), respectively. The coefficient of determination (R2) was 21% with a mean difference of 1.7 g/dL (SD = 1.1 g/dL; range: −0.9–4.3 g/dL). In the multivariable model, the Ref Hb level (P = 0.001) was the only statistically significant predictor. Conclusion: The Pronto-7® pulse CO-oximetry device was found to overestimate Hb levels in patients with TM and therefore cannot be recommended. Further larger studies are needed to confirm these results."
    }
]