[
    {
        "id": "osp-12537",
        "type": "article-journal",
        "title": "Efficacy of three different formulations of brimonidine for control of intraocular pressure in primary open-angle glaucoma: A 6-week randomized trial",
        "author": [
            {
                "family": "Bhatti",
                "given": "Anubha"
            },
            {
                "family": "Singh",
                "given": "Gursatinder"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/efficacy-of-three-different-formulations-of-brimonidine-for-control-of-intraocular-pressure-in-primary-open-angle-glaucoma-a-6-week-randomized-trial",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2018
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "11",
        "issue": "2",
        "page": "140-143",
        "DOI": "10.4103/ojo.ojo_98_2016",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Background: To compare the intraocular pressure (IOP)-lowering efficacy and safety of brimonidine (0.2%), brimonidine purite (0.15%), and brimonidine purite (0.1%) in patients of primary open-angle glaucoma (POAG).\n\nMaterials and methods: Sixty patients of POAG with IOP >21 mmHg were enrolled into this study for 6-week duration. The patients were randomly divided into three groups with 20 patients in each group. Group A instilled brimonidine 0.2%, Group B instilled brimonidine purite 0.15%, and Group C instilled brimonidine purite 0.1% twice daily. IOP was recorded by applanation tonometry at baseline and subsequently at 2, 4, and 6 weeks at 9:00-10:00 am during each visit around 30 min after instillation of eye drops.\n\nResults: Mean IOP reduction in Group A was from 25.55 ± 2.01 to 19.85 ± 2.05 mmHg at the end of study, thus resulting in fall of 5.70 mmHg (22.30%), in Group B, it decreased from 25.65 ± 2.41 to 19.55 ± 2.43 mmHg, thus resulting in fall of 6.10 mmHg (23.78%), and in Group C, it decreased from 25.80 ± 2.26 mmHg to 19.85 ± 2.16 mmHg, thus resulting in fall of 6.35 mmHg (24.61%). There was no statistically significant difference in IOP-lowering efficacy of study drugs. Conjunctival hyperemia, foreign body sensation, dry eye, and papillary reaction were the important side effects seen with study drugs. Brimonidine 0.2% caused more side effects than brimonidine purite 0.15% and brimonidine purite 0.1%.\n\nConclusion: All the three formulations of brimonidine produced statistically equal lowering of IOP in patients of POAG with reduced systemic and ocular adverse reactions with brimonidine purite 0.15% and 0.1%."
    }
]