[
    {
        "id": "osp-9908",
        "type": "article-journal",
        "title": "Efficacy of Hormonal and Non-Hormonal Vaginal Gel Preparations on the Female Sexual Satisfaction Index in Postmenopausal Women with Sexual Dysfunction Syndrome: A PRISMA-compliant meta-analysis",
        "author": [
            {
                "family": "Soliman",
                "given": "Ahmed"
            },
            {
                "family": "Alrashidi",
                "given": "Hanaa"
            },
            {
                "family": "Ghorab",
                "given": "Mohamed A."
            },
            {
                "family": "Reem",
                "given": ""
            },
            {
                "family": "Al Riyami",
                "given": "Nihal"
            },
            {
                "family": "Ashour",
                "given": "Ahmed SA"
            },
            {
                "family": "Mohammed",
                "given": "Yasmine A."
            },
            {
                "family": "Saad",
                "given": "Ahmed H."
            }
        ],
        "URL": "https://omanscience.com/ar/articles/efficacy-of-hormonal-and-non-hormonal-vaginal-gel-preparations-on-the-female-sexual-satisfaction-index-in-postmenopausal-women-with-sexual-dysfunction",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "25",
        "issue": "1",
        "page": "17-29",
        "DOI": "10.18295/squmj.6.2024.040",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "This meta-analysis aimed to compare the efficacy of vaginal gel preparations versus placebo in postmenopausal women with sexual dysfunction syndrome. Searches of electronic databases from inception to January 2023 identified 8 trials (N = 672) that reported the Female Sexual Function Index (FSFI) and compared hormonal (oestrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions against placebo. The Cochrane Risk of Bias tool was used to assess studies' quality. The vaginal gel group had a significantly higher total FSFI endpoint score (mean difference [MD] = 6.67, 95% confidence interval [CI]: 3.79--9.55; P < 0.001) than placebo. Non-hormonal gels exhibited a greater FSFI total score (MD = 6.73, 95% CI: 4.7--8.76; P < 0.001) than hormonal gels (MD = 2.75, 95% CI: 1.87--3.64; P < 0.001), positively impacting all FSFI domains. These findings indicate that chamomile and fennel vaginal gels may improve the overall FSFI 6 domains score, reflecting enhancements in postmenopausal women's sexual activity and satisfaction."
    }
]