[
    {
        "id": "osp-11556",
        "type": "article-journal",
        "title": "Effect of N-acetyl-L-cysteine on Cytokine Production by Human Peripheral Blood Mononuclear Cells",
        "author": [
            {
                "family": "Al-Shukaili",
                "given": "Ahmed"
            },
            {
                "family": "Al Abri",
                "given": "Suad"
            },
            {
                "family": "Monteil",
                "given": "Alia"
            },
            {
                "family": "A.",
                "given": "Michele"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/effect-of-n-acetyl-l-cysteine-on-cytokine-production-by-human-peripheral-blood-mononuclear-cells",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "9",
        "issue": "1",
        "page": "70-74",
        "DOI": "10.18295/2075-0528.2765",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: This study investigates the in vitro effect of the antioxidant drug, N-acetyl-L-cysteine (NAC), on cytokine production by peripheral blood mononuclear cells (PBMC). Methods: PBMC were isolated by Ficoll-Hypaque, and stimulated with anti-CD3 antibodies, phytohaemagglutinin (PHA), lipopolysaccharide (LPS) for 24 hours in the presence or absence of 5 mM NAC. The cytokines produced were measured by enzyme-linked immunosorbent assay (ELISA). Results: Treatment with NAC significantly up-regulates the secretion of IL-1β, IL-5 (interleukin) and IFN-γ (interferon) and down regulates IL-10 production, after anti-CD3 or PHA (p"
    }
]