[
    {
        "id": "osp-12446",
        "type": "article-journal",
        "title": "Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus",
        "author": [
            {
                "family": "Fernandes",
                "given": "Sheldon Ignatius"
            },
            {
                "family": "Nagpal",
                "given": "Shubha"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/corneal-thickness-and-endothelial-cell-density-in-children-with-type-1-diabetes-mellitus",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2019
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "12",
        "issue": "3",
        "page": "186-190",
        "DOI": "10.4103/ojo.ojo_21_2018",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Background: The aim of this study was to detect the effect of diabetes on the corneal endothelium in patients of Type 1 diabetes in the pediatric age group and to compare them with age-matched controls. Further, it was proposed to establish any correlation between these changes and risk factors of diabetes, viz., age, duration of diabetes, and hemoglobin A1c (HbA1c) values.\n\nMaterials and methods: This was a prospective cross-sectional study. Fifty children with Type 1 diabetes, between the ages of 7 and 17 years (average, 12.16 ± 2.63 years), and fifty healthy age-matched controls (average 12.28- ±3.00 years) were examined. The central corneal thickness (CCT) and endothelial cell density (CD) were assessed by the Topcon SP-1P specular microscope. The duration of diabetes (average, 3.91 ± 1.65 years) and the HbA1c values (average, 10.92 ± 2.28) were also noted.\n\nResults: The average CCT in the diabetics was 525.16 ± 33.14 μ and in the controls 513.44 ± 29.46 μ. This was significantly higher (P = 0.015). The average endothelial CD in the diabetics was 3039.64 ± 292.84 cells/mm2 and in the nondiabetics 3360.41 ± 268.04 cells/mm2. This was significantly lower (P < 0.001). A significant correlation was found between the endothelial CD and age of the diabetic patients (P = 0.008). However, there was no significant correlation between the endothelial CD and the CCT with either duration of diabetes or HbA1c.\n\nConclusions: A significant decrease in the endothelial CD and increase in the CCT occurs in children and adolescents with Type 1 diabetes. With the age of the diabetic patients, the endothelial CD significantly reduces. However, duration of diabetes and HbA1c do not affect these values."
    }
]