[
    {
        "id": "osp-11719",
        "type": "article-journal",
        "title": "Calculation of the Inactivation Cross Section of V79 Cells by Protons in Radiotherapy",
        "author": [
            {
                "family": "Azooz",
                "given": "Faika A."
            },
            {
                "family": "Alkhalidy",
                "given": "Thamer J."
            }
        ],
        "URL": "https://omanscience.com/ar/articles/calculation-of-the-inactivation-cross-section-of-v79-cells-by-protons-in-radiotherapy",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "7",
        "issue": "3",
        "page": "233-238",
        "DOI": "10.18295/2075-0528.2673",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objective: For efficient applications of protons in radiotherapy, detailed knowledge of the corresponding radiobiological mechanism is necessary. The inactivation cross section is a useful tool to explore the interaction mechanism. Hence, the inactivation cross section for proton irradiation on V79 cells has been calculated using published survival data. Method: The linear quadratic equation was used to fit the survival curves and the parameter α was used to calculate the cross section. The cross section σ is plotted as a function of the mean free path λ and the linear energy transfer LET. Results: The cross section σ-versus-λ curve shows a saturation region between λ≥2 nm and λ≤5 nm. In this region, the inactivation cross section value is about the same as the geometrical area of the DNA segment (≈4 μm2). Such a saturation is also seen in the σ-LET curve. Conclusion: This implies that one DNA segment is at a risk upon the traversal of a single proton."
    }
]